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KMID : 0352519820190010437
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Korea Univercity Medical Journal
1982 Volume.19 No. 1 p.437 ~ p.444
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Clinical Study of Adequate Dose of d-Tubocurarine Chioride for Endotracheal Intubation
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蔡秉國/Chae, Byung-Kook
吉燦一/辛正順/Gill, Chan-Il/Shin, Jeong-Soon
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Abstract
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Administration of succinylcholine for endotracheal intubation may cause untoward reactions such as elevation of intraocular pressure, increased plasma potassium level, increased int--ragastric pressure, bradycardia, and development of postoperative muscle pain, etc.
Several attempts have been made to minimize the development of muscle fasciculation folluowing administration of succinylcholine such as pretreatment with small doses of nondepolarizing neuromuscular blocking agent, self-taming of succinylcholine, or the use of hexafluorenium.
When small doses of nondepolarizing neuromuscular blocking agent are given before succinylcholine administration, larger doses of succinylcholine should be given to achieve satisfactory relaxation. So, this study was intended to determine the adequate doses of d-tubocurar--ine chloride (d-Tc) for endotracheal intubation in patients with relative contraindication of -using succinylcholine.
We Observed the degree of vocal cord relaxation 3 minute after d-Tc administration by liberscopic examination and measured changes in mean blood pressure (MBP) and heart rate, just before, and after intubation, and 5 minutes after intubation.
The total number of patients in this study was 100, and the patients were divided into live groups:
Group 1, consisting of 10 patients, recieved 0.3mg/kg of d-tubocurarine.
Group 2, of 32 patients, recieved 0.4 mg/kg of d-Tc.
Group 3, of 16 patients, recieved 0.45 mg/kg of d-Tc.
Group 4, of 26 patients, recieved 0. 5 mg/kg of d-Tc.
Group 5, of 16 patients, recieved 0.6 mg/kg of d-Tc.
The conclusions are summarized as follows;
1) The adequate doses of d-Tc for endotracheal intubation is 0.5 mg/kg.
2) Maximum reductions in MBP were present 3 minutes following d-Tc administration in each group.
3) Heart rate did not change significantly after d-Tc administration in each group.
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